Sacral Nerve Stimulation

Spinal Cord Stimulation for Chronic Pain

 

About Sacral Nerve Stimulation

Millions of patients experience bladder control problems, including urinary urge incontinence, non-obstructive urinary retention, and significant symptoms of urgency-frequency.

Medtronic offers an innovative intervention for overactive bladder and urinary retention called sacral nerve stimulation (InterStim® Therapy) in patients who have failed or could not tolerate more conservative treatments. The intervention provides urinary control therapy that addresses the nerve component of bladder control problems.1, 2

  • Over 55,000 patients have received sacral nerve stimulation worldwide*
  • Minimally invasive test & implant procedure
  • Over 11 years being FDA approved
  • Proven efficacy in patients for whom more conventional therapy has been unsatisfactory 2-9

Indications

Sacral nerve stimulation (InterStim® Therapy) is indicated for patients who haven't had success with urinary control medication, and who suffer from one or more of the following conditions:

  • Urinary urge incontinence
  • Urinary urgency-frequency
  • Non-obstructive urinary retention

Contraindications

Diathermy. Patients who have not demonstrated an appropriate response to test stimulation or are unable to operate the neurostimulator.

 

* Data from InterStim Sales Analysis. Medtronic, Inc. August 2008.

References

  1. Schmidt RA, Jonas U, Oleson KA, et al, for the Sacral Nerve Stimulation Study Group. Sacral nerve stimulation for treatment of refractory urinary urge incontinence. J Urol. 1999;162:352-357.
  2. Siegel SW, Catanzaro F, Dijkema HE, et al. Long-term results of a multicenter study on sacral nerve stimulation for treatment of urinary urge incontinence, urgency-frequency, and retention. Urology. 2000;56(suppl 6A):87-91.
  3. Janknegt RA, Hassouna MM, Siegel SW, et al. Long-term effectiveness of sacral nerve stimulation for refractory urge incontinence. Eur Urol. 2001;39:101-106.
  4. Weil EHJ, Ruiz-Cerdá JL, Eerdmans PHA, Janknegt RA, Bemelmans BLH, van Kerrebroeck PhEV. Sacral root neuromodulation in the treatment of refractory urinary urge incontinence: a prospective randomized clinical trial. Eur Urol. 2000;37:161-171. <
  5. Hassouna MM, Siegel SW, Lycklama à Nÿeholt AAB, et al. Sacral neuromodulation in the treatment of urgency-frequency symptoms: a multicenter study on efficacy and safety. J Urol. 2000;163:1849-1854.
  6. Jonas U, Fowler CJ, Chancellor MB, et al. Efficacy of sacral nerve stimulation for urinary retention: results 18 months after implantation. J Urol. 2001;165:15-19.
  7. Aboseif S, Tamaddon K, Chalfin S, et al. Sacral neuromodulation in functional urinary retention: an effective way to restore voiding. BJU Int. 2002;90:662-665.
  8. Spinelli M, Bertapelle P, Cappellano F, et al, for the GINS Group. Chronic sacral neuromodulation in patients with lower urinary tract symptoms: results from a national register. J Urol. 2001;166:541-545.
  9. Schmidt RA, Jonas U, Oleson KA, et al, for the Sacral Nerve Stimulation Study Group. Sacral nerve stimulation for treatment of refractory urinary urge incontinence. J Urol. 1999;162:352-35

Treatment & Diagnosis

How it Treats Overactive Bladder*

Mild electrical pulses stimulate the nerves that provide the most distal common autonomic and somatic nerve supply to the pelvic floor and lower urinary tract. 2, 6

Sacral nerve stimulation offers: 

  • Effective urinary control1-6
  • Proven efficacy in patients for whom more conventional intervention has been unsatisfactory1-6
  • Minimally invasive test & implant procedure

*The precise mechanism of action has not been established.

References

  1. Schmidt RA, Jonas U, Oleson KA, et al, for the Sacral Nerve Stimulation Study Group. Sacral nerve stimulation for treatment of refractory urinary urge incontinence. J Urol. 1999;162:352-357.
  2. Weil EHJ, Ruiz-Cerdá JL, Eerdmans PHA, Janknegt RA, Bemelmans BLH, van Kerrebroeck PhEV. Sacral root neuromodulation in the treatment of refractory urinary urge incontinence: a prospective randomized clinical trial. Eur Urol. 2000;37:161-171.
  3. Hassouna MM, Siegel SW, Lycklama à Nÿeholt AAB, et al. Sacral neuromodulation in the treatment of urgency-frequency symptoms: a multicenter study on efficacy and safety. J Urol. 2000;163:1849-1854.
  4. Jonas U, Fowler CJ, Chancellor MB, et al. Efficacy of sacral nerve stimulation for urinary retention: results 18 months after implantation. J Urol. 2001;165:15-19.
  5. Aboseif S, Tamaddon K, Chalfin S, et al. Sacral neuromodulation in functional urinary retention: an effective way to restore voiding. BJU Int. 2002;90:662-665.
  6. Spinelli M, Bertapelle P, Cappellano F, et al, for the GINS Group. Chronic sacral neuromodulation in patients with lower urinary tract symptoms: results from a national register. J Urol. 2001;166:541-545.